Throughout the 17th century the fortress remained in Venetian hands and was a refuge for Christians fleeing from the Turks. In 1715, however, a Turkish Pasha managed to conquer the castle; after a long siege the Venetians capitulated and a treaty was signed.
After that, Turkish families who were afraid of the Christians inhabited the castle. After the Turks were driven out of Crete in 1903, the fortress was turned into a leper colony.